EFFECTS OF SOME Ca~(2+) BLOCKER ON RECEPTOR POTENTIALS OF CRAYFISH RETINA

• 作 者: 蔡浩然 H.STIEVE
• 机 构: Institute of Biophysics, Academia Sinica, Beijingrrrrrrrrn,Institute of Neurobiology, KFA,
• 出 处: Science in China,Ser.B
• 发表日期: 1986年03期
• 关键词: retina calmodulin saline progressive thereafter raised prolonged alone ventral i

One drug known to inactivate calmodulin and two others to block Ca~(2+) channels were applied to isolated superfused retinae of the crayfish Astacus leptodactylus and their influence on the receptor potentials (RP) was studied. Trifluoperazine causes an increase of the amplitude of maximum (h_(max))of RP and a prolongation of the time of half decrease (t_2). Furthermore, trifluoperazine could antagonise the effect of raised calcium concentration of superfusate, which decreases h_(max) and shortens t_2 of the RP. Iproveratril and D-600 cause a transient increase and thereafter a progressive decrease of h_(max) of the RP. There is a difference between effects of both drugs on t_2 of the RP. The mechanisms of effects of these drugs on the sensitivity of the isolated retina are discussed.

One drug known to inactivate calmodulin and two others to block Ca ~ (2+) channels were applied to isolated superfused retinae of the crayfish Astacus leptodactylus and their influence on the receptor potentials (RP) was studied. Trifluoperazine causes an increase of the amplitude of maximum (h_ (max)) of RP and a prolongation of the time of half decrease (t_2). Furthermore, trifluoperazine could antagonize the effect of raised calcium concentration of superfusate, which decreases h_ (max) and shortens t_2 of the RP. Iproveratril There are a difference between effects of both drugs on t_2 of the RP. The mechanisms of effects of these drugs on the sensitivity of the isolated retina are discussed.