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目的：了解虎门镇虎门医院和太平人民医院成人重症监护病房（ICU）病房葡萄球菌耐药情况。方法对我院ICU病房2009年1月-2013年12月送检标本中所分离的葡萄球菌耐药率进行回顾性分析。结果5年间ICU病房共检出葡萄球菌707株，其中金黄色葡萄球菌474株（占67.0%）,耐甲氧西林金黄色葡萄球菌（MRSA）检出率为91.7%；凝固酶阴性葡萄球菌233株（占33.0%），耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）检出率为96.1%。居前三的标本来源为呼吸道、血及伤口分泌物，分别占85.4%，7.8%和4.1%。葡萄球菌对万古霉素、替考拉宁及利奈唑胺全敏感，对利福平、复方新诺明耐药性较低，对其他抗菌药物的耐药性较高。结论 ICU病房葡萄球菌主要来源于呼吸道，MRSA、MRCNS检出率高，且呈多重耐药趋势，应依据药敏结果来选择用药。“,”OBJECTIVES To investigate drug resistance of Staphylococcus from intensive care unit(ICU) in our hospital. METHODS A retrospective analysis of drug sensitivity test of Staphylococcus in ICU from Jan,2009 to Dec,2013 were col ected.RESULTS There were 707 strains of Staphylococcus in 5 years,including 474 strains staphylococcus aureus, of which 91.7% were methicil in-resistant staphylococcus aureus(MRSA) and 233 strains coagulase negative staphylococcus,of which 96.1% were methicil in-resistant coagulase negative staphylococcus(MRCNS).The pathogens were isolated from the respiratory tract(85.4%), bloodstream(7.8%) and wound (4.1%). Staphylococcus were 100% sensitive to vancomycin,linezolid and teicoplanin and it showed low rates of resistance to rifampicin and sulfamethoxazole.However the resistance rate of other antibiotics were high. CONCLUSION ICU infection of Staphylococcus were most common in the respiratory tract. The relevance ratio of MRSA and MRCNS were high and they showed multi-drug resistance tendency. It should be based on the susceptibility patterns to the choice of drugs.