论文部分内容阅读
母亲HIV阳性的婴儿中HIV感染的诊断可以在出生头12个月内进行,但很少有在出生头几周内检查HIV的情况.本文作者报告了一项前瞻性纵向研究,结果支持HIV-1可在围产期末或分娩时传播的假设.作者从1990年1月开始前瞻性研究了巴黎两家产科医院血清HIV阳性母亲所生婴儿的感染情况.分别在出生后4～9天、4～9周和5～9月龄时抽取外周血(3ml).婴儿随访在6月龄内每月一次,以后2或3个月一次.到1991年7月,共有50例血清HIV阳性母亲所生的婴儿参加研究.用PCR、病毒培养、HIV-1血清学和p24抗原检测法检测血液标本中的HIV-1.结果:在出生时,有5例婴儿PCR阳性,其中3例可检出p24抗原血症,2例
HIV infection in mothers with HIV-positive infants can be diagnosed within the first 12 months of life, but very few have been examined for HIV in the first few weeks of life.The authors report a prospective longitudinal study that supports HIV- 1 can be transmitted at the end of the perinatal period or during childbirth.The author began a prospective study of the infection of infants born to HIV-positive mothers in two maternity hospitals in Paris since January 1990. Four to nine days after birth, 4 Peripheral blood (3 ml) was withdrawn at ~ 9 weeks and at 5 to 9 months of age Infants were followed up once every 6 months and then 2 or 3 months Later, in July 1991, a total of 50 HIV positive mothers The infants were enrolled in the study, HIV-1 in blood samples was detected by PCR, virus culture, HIV-1 serology and p24 antigen test.Results: Five infants were PCR positive at birth, of which 3 were detectable p24 antigenemia, 2 cases