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作者报告一例男性患者,64岁,因气促、吞咽困难一个月,而来就诊,一年来体重减少40磅,皮肤紧硬,双手指活动受限。查体:消瘦,整个面部手、脚、皮肤紧张、发亮、萎缩,双手未形成溃疡,无指关节痛、关节肿胀及软组织钙化,手指表现为屈曲性挛缩。X线胸部检查发现左肺门团块,左上叶支气管活检证明为小细胞未分化癌。经各种扫描、放射线摄片及骨髓检查,未发现转移。实验室检查:ANA升高,滴度1:1200,呈现斑点型免疫荧光,类风湿因子(一),血常规及血生化检验无特殊,手指皮肤活检证实为硬皮病。经数疗程联合化疗及左肺
The authors report a male patient, 64, who was diagnosed due to shortness of breath and difficulty swallowing for one month to seek treatment. He lost 40 pounds a year and had tight skin with limited finger movement. Examination: weight loss, the entire face hands and feet, skin tension, shine, atrophy, hands did not form ulcers, no knuckles pain, joint swelling and soft tissue calcification, finger performance of flexion contracture. X-ray chest examination revealed left hilar mass, left upper lobe bronchial biopsy proved to be small cell undifferentiated carcinoma. After a variety of scanning, radiography and bone marrow examination, no metastasis was found. Laboratory tests: ANA increased, titer 1: 1200, showing immunofluorescence, rheumatoid factor (a), blood and blood biochemical tests were no specific, finger skin biopsy confirmed as scleroderma. After several courses of chemotherapy and left lung