Efficient synthesis and in vitro antifungal activity of 1H-benzimidazol-l-yl acetates/propionates co

• 作 者: Pei Zhi Zhang Shao Fang Zhou Tian Ren Li Lin Jiang
• 机 构: College of Chemistry and Material Science,Shandong Agricultural University,
• 出 处: Chinese Chemical Letters
• 发表日期: 2012年12期
• 关键词: antifungal moiety cinerea Botrytis triazole microwave irradiation dibenzo antiba

A series of novel 1H-benzimidazol-1-yl acetates and 1H -benzimidazol-1-yl propionates containing 1H-1,2,4-triazole moiety were synthesized under microwave irradiation by multi-step reactions,in yields of 87-94%.Their in vitro antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum were evaluated by mycelial growth rate method.All the target compounds exhibit high activities against B.cinerea with the EC_(50) values of 7.96-21.74μg/mL,higher than that of carbendazim.

A series of novel 1H-benzimidazol-1-yl acetates and 1H -benzimidazol-1-ylpropionates containing 1H-1,2,4-triazole moiety were synthesized under microwave irradiation by multi-step reactions, yield of 87-94% Their in vitro antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum were evaluated as mycelial growth rate method. All the target compounds exhibit high activities against B.cinerea with the EC 50 values ​​of 7.96-21.74 μg / mL, higher than that of carbendazim.