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目的:探讨静息状态下未服药强迫症患者双侧杏仁核功能连接的模式。方法:纳入符合ICD-10中强迫症诊断标准的40例未服药强迫症患者（强迫症组），38名在性别、年龄和受教育程度与之相匹配的健康对照者（对照组）。采用Y-BOCS、HAMDn 17、HAMA评估强迫思维、强迫行为以及抑郁、焦虑症状。所有被试者进行全脑静息态fMRI，以左右杏仁核为种子点，采用基于体素的全脑功能连接方法分析强迫症患者静息状态下双侧杏仁核的功能连接模式；采用皮尔逊相关分析方法探讨强迫症患者异常功能连接与临床症状之间的关系。n 结果:与对照组相比，强迫症组左侧杏仁核与右背侧前脑岛（0.16±0.13与0.27±0.13，n t=-2.75，n P<0.05，高斯随机场理论校正）、左侧杏仁核与左腹侧前扣带回（0.09±0.12与0.19±0.13，n t=-3.40，n P<0.05，高斯随机场理论校正）功能连接降低；强迫症组左侧杏仁核与右背侧前脑岛之间功能连接n Z值与HAMA总分呈正相关（n r=0.377，n P=0.016，未校正）。n 结论:静息状态下未服药强迫症患者情绪调节网络功能连接降低；左侧杏仁核与右背侧前脑岛之间降低的功能连接可能与强迫症患者的焦虑症状相关。“,”Objective:To explore the pattern of resting-state functional connectivity of bilateral amygdale in drug-naive obsessive-compulsive disorder (OCD).Methods:Forty patients with OCD matched the criteria of International Classification of Diseases-10 and 38 gender-, age-, education-matched healthy subjects participated in the resting-state brain functional magnetic resonance imaging scan. The Yale-Brown Obsessive-Compulsive Scale, 17-Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale (HAMA) were used to assess the clinical symptoms of obsession, compulsion, depression and anxiety. Based on the Data Processing & Analysis for (Resting-State) Brain Imaging software, a voxel-based functional connectivity approach was used to explore the pattern of resting-state functional connectivity of bilateral amygdala in OCD; Pearson correlation analyses was used to analyze the relationship between the abnormal functional connectivity values and clinical symptoms in OCD.Results:Compared with the controls, patients with OCD showed decreased functional connectivity values between left amygdale and right dorsal anterior insula (0.16±0.13 n vs. 0.27±0.13, n t=-2.75, n P<0.05, Gaussian random field (GRF) corrected, two-tailed), and between left amygdale and left ventral anterior cingulate cortex (0.09±0.12 n vs. 0.19±0.13, n t=-3.40, n P<0.05, GRF corrected, two-tailed). The functional connectivity between left amygdale and right dorsal anterior insula was positively correlated with HAMA total score (n r=0.377, n P=0.016, uncorrected).n Conclusions:At resting-state, the functional connectivities of the emotional regulation network decreased in drug-naive patients with OCD. Decreased functional connection between left amygdale and right dorsal anterior insula may be associated with anxiety symptoms in patients with OCD.