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结核病一直是威胁人类健康的全球性公共卫生问题,耐多药结核病的蔓延、结核/HIV双重感染的流行、人口流动的加剧等使结核病控制面临更为严峻的挑战。更为值得关切的是结核病基础研究薄弱,迄今为止我们还未弄清结核杆菌如何致病,自卡介苗以后没有研制出更为有效的新型疫苗,近50年没有开发出1种抗结核新药,主要利用“涂片+培养+X线检查”这种效率不高的结核病主体诊断模式依旧没有改变,严重阻碍了人类控制结核病的进程!在本专题中,有对重视和加强结核病基础研究的激情呼吁,有对结核病基础研究现状的评述和未来发展的展望,有目前鲜见同类文献的研究报道,我们热切地希望通过这个专题能使结核病的基础研究得到更多的关注,并期待有更多的突破!
Tuberculosis has always been a global public health problem that threatens human health. The spread of multi-drug resistant tuberculosis (TB), the prevalence of TB / HIV co-infection, and the increase in population flows have posed even more serious challenges to tuberculosis control. More concern is that the basic research on tuberculosis is weak. So far, we have not yet figured out how Mycobacterium tuberculosis causes disease. Since BCG has not developed a more effective new vaccine, no new antituberculosis drug has been developed in the past 50 years, mainly The use of “smear + culture + X-ray examination,” the inefficient diagnosis mode of tuberculosis remains unchanged, seriously hindered the process of human control of tuberculosis! In this topic, there is emphasis on and strengthen the basic research of tuberculosis Passion appeal, comments on the status quo of TB basic research and prospects for future development, with few reports of similar literature at present, and we sincerely hope that this topic will give more attention to the basic research on TB and look forward to more More breakthroughs!