论文部分内容阅读
概述了活性代谢物血液浓度监测的意义,主要涉及药物血浆浓度-效应关系的不一致及代谢物-药物的相互作用;根据药物动力学原理及概念,介绍代谢物动力学参数的测定法,以及如何从单次给药数据预测代谢物的稳态浓度。
The significance of blood concentration monitoring of active metabolites is summarized, including the inconsistency of drug plasma concentration-response relationship and the interaction of metabolite-drug. According to the principles and concepts of pharmacokinetics, the determination of metabolite kinetics parameters and how Predict metabolite steady state concentration from single dose data.