TCR_3—鸡类第三种T细胞抗原受体

• 作 者: 朱炳法 彭整军
• 出 处: 国外医学(免疫学分册)
• 发表日期: 1989年06期
• 关键词: 抗原受体 TCR_3 保守性 多些 β链 类中 胸腺 异二聚体 部分水解 亚群

哺乳类大多数T 细胞所表达的T 细胞抗原受体(TCR)由α、β链组成(TCR_2);少数T 细胞则为γ、δ链组成TCR_1:它们常与CD_3联结。禽类中相似哺乳类TCR_1,FCR_2的结构已用单抗被鉴定。虽然两类TCR 有一定保守性,但鸟类TCR_1的量比哺乳类多些。本文报道鸡的第三类TCR(TCR_3)。

T-cell antigen receptors (TCRs) expressed by most mammalian T cells are composed of α, β chains (TCR_2); a few T cells are γ, and δ chains consist of TCR_1: they are often associated with CD_3. The structures of similar mammalian TCR_1 and FCR_2 in birds have been identified using monoclonal antibodies. Although both types of TCRs are somewhat conserved, birds have more TCR_1 than mammals. This article reports a third type of chicken TCR (TCR_3).