内皮祖细胞捕获支架的困惑与希望

• 作 者: 沈雳 葛均波
• 机 构: 复旦大学附属中山医院心内科 上海市心血管病研究所,复旦大学附属中山医院心内科 上海市心血管病研究所,
• 出 处: 中国分子心脏病学杂志
• 发表日期: 2006年03期
• 关键词: 内皮祖细胞 内皮化 再狭窄 支架

药物洗脱支架显著减少了支架内再狭窄的发生,但同时过度的抑制了支架局部的内皮层的自然愈合,影响了其远期疗效。随着内皮祖细胞(endothdial progenitor cells,EPCs)的研究进展, 通过动员外周血EPCs到血管局部并修复损伤内皮成为抗再狭窄的新策略之一,由此理论产生的 EPCs捕获支架正成为一种颇具前景的新型功能化支架。然而目前的EPCs捕获支架仍不成熟,其抗再狭窄功能没有充分体现,但随着对EPCs分化机制和调控的研究逐步深入,以及支架的生物工程化制作工艺的不断改善,EPCs捕获支架作为一种具有加速内皮修复功能的新型支架,在冠心病的介入治疗中将占有重要地位,并将启发人们研制更多的功能化支架。

Drug-eluting stents significantly reduce the incidence of in-stent restenosis, but at the same time, it over-inhibits the natural healing of the local endothelium and affects its long-term efficacy. With the development of EPCs, one of the new strategies of resisting restenosis by mobilizing peripheral blood EPCs to local blood vessels and repairing the damaged endothelium is becoming a kind of EPCs capture scaffold Promising new functional bracket. However, the current EPCs capture scaffolds are still not mature, and their anti-restenosis function is not fully reflected, but with the research of EPCs differentiation mechanism and regulation progressively deepened, and the continuous improvement of the bioengineering process of scaffolds, EPCs capture scaffolds as a The new scaffold with accelerated endothelial repair will play an important role in the interventional treatment of coronary heart disease and will inspire people to develop more functional scaffolds.