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目的 :评估预防性抗生素应用对急性有机磷中毒 (AOPP)患者医院感染的影响。方法 :对 15 8例AOPP患者随机分为预防性抗生素应用组 (A组 )和对照组 (B组 ) ,A组在常规治疗的基础上于入院当日给予抗生素预防性应用 (氨苄青霉素加氧氟沙星或单用头孢噻肟钠 ) ,连用 5～ 7d ;B组除常规治疗外 ,未预防性应用抗生素 ;统计两组在医院感染率和死亡率的差异。结果 :A组医院感染率 12 8% ,B组医院感染率为 3 6 1% ,两组比较有显著差异 (P <0 0 1) ;A组死亡率为 9 3 % ,低于B组的 3 0 6%。结论 :AOPP患者预防性应用抗生素 ,可明显降低医院感染率和死亡率。
Objectives: To assess the impact of prophylactic antibiotics on nosocomial infections in patients with acute organophosphate poisoning (AOPP). Methods Fifty-eight patients with AOPP were randomly divided into prophylactic antibiotic group (group A) and control group (group B). Group A was given antibiotic prophylaxis on the basis of routine treatment on the day of admission (ampicillin plus oxyfluoride Shaoxing or Cefotaxime sodium alone), once every 5 to 7 days. In addition to conventional treatment, antibiotics were not used in group B, and the difference in hospital infection rate and death rate was statistically analyzed. Results: The infection rate of hospital in group A was 12.8%, and that of group B was 36.1%. There was significant difference between the two groups (P <0.01). The mortality of group A was 93%, which was lower than that of group B 3 0 6%. Conclusion: The prophylactic use of antibiotics in patients with AOPP can significantly reduce the hospital infection rate and mortality.