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目的探讨抑癌基因与大肠肿瘤发生过程的关系,以及对大肠癌早期诊断及预后判断的价值。方法150例大肠肿瘤标本,其中腺癌50例,腺癌伴转移16例,腺瘤伴癌变24例,腺瘤伴异型增生28例、腺瘤32例,采用免疫组化SP法检测p53、p16、nm23和PCNA基因的表达情况。结果p53、p16、nm23、PCNA基因蛋白在大肠腺瘤、腺瘤伴异型增生、腺瘤癌变、腺癌、腺癌伴转移中的表达差异显著。结论p53和p16检测有助于大肠肿瘤早期诊断,nm23和PCNA为预后判断的重要指标。
Objective To investigate the relationship between tumor suppressor gene and the development of colorectal cancer and its value in the early diagnosis and prognosis of colorectal cancer. Methods A total of 150 cases of colorectal tumor specimens including 50 cases of adenocarcinoma, 16 cases of adenocarcinoma with metastasis, 24 cases of adenoma with carcinomatosis, 28 cases of adenoma with dysplasia and 32 cases of adenoma were detected by immunohistochemical SP method. , Nm23 and PCNA gene expression. Results The expressions of p53, p16, nm23 and PCNA proteins in colorectal adenoma, adenoma with dysplasia, adenoma, adenocarcinoma and adenocarcinoma were significantly different. Conclusion The detection of p53 and p16 contribute to the early diagnosis of colorectal cancer, nm23 and PCNA are important prognostic indicators.