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目的:观察金氏肾炎汤加减治疗对减少肾病综合征糖皮质激素不良反应的疗效。方法:将入选的55例患者随机分为对照组和治疗组,分别进行每两周测尿蛋白定量、尿常规、血浆白蛋白、血脂一次,每月测血常规、肝功一次,观察治疗前后指标的变化,1个月为1个疗程,共治疗3个疗程。结果:两组疗效比较,治疗组30例患者经3个疗程治疗后显效20例,有效6例,无效4例,总有效率86.7%。对照组25例显效8例,有效6例,无效11例,总有效率达56%。经检验,治疗组与对照组疗效差异有统计学意义(P<0.05),治疗组优于对照组。治疗组24小时尿蛋白定量、血浆白蛋白、血脂较对照组明显改善(P<0.05),且中医证侯积分均有明显改善(P<0.05)。结论:金氏肾炎汤对减少肾病综合征糖皮质激素不良反应有较好的疗效。
Objective: To observe the curative effect of jinshidongyan decoction on reducing glucocorticoid adverse reaction of nephrotic syndrome. Methods: Fifty-five selected patients were randomly divided into control group and treatment group. Urinary protein, urine routine, serum albumin and lipids were measured every two weeks. Blood routine and liver function were measured every month. Changes in indicators, 1 month for a course of treatment, a total of 3 courses of treatment. Results: Compared the curative effect of two groups, 30 patients in the treatment group were markedly effective after 3 courses of treatment, 6 were effective, 4 were ineffective and the total effective rate was 86.7%. The control group of 25 cases markedly effective in 8 cases, effective in 6 cases, ineffective in 11 cases, the total effective rate of 56%. After testing, the treatment group and the control group, the difference was statistically significant (P <0.05), the treatment group than the control group. The 24-hour urinary protein, serum albumin and serum lipids in the treatment group were significantly improved (P <0.05), and the Houzheng scores of TCM syndromes were significantly improved (P <0.05). Conclusion: Jinshenyin Decoction has a good curative effect on reducing glucocorticoid adverse reaction of nephrotic syndrome.