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目的研究胃癌ＣＤ４４的表达及其预后意义。方法应用免疫组织化学ＳＰ方法，研究１１０例胃癌手术标本中ＣＤ４４的表达。结果胃癌原发灶中ＣＤ４４表达阳性率为５３．６４％（５９／１１０）；ＣＤ４４表达与癌组织浸润胃壁深度、区域淋巴结转移与否及胃癌临床病理学分期的进展呈密切正相关（Ｐ＜０．０５）。ＣＤ４４表达阴性组患者术后３年、５年生存率明显高于ＣＤ４４表达阳性组（Ｐ＜０．０１）。结论ＣＤ４４可能参与胃癌的浸润和淋巴结转移过程；ＣＤ４４表达阴性患者预后好。检测胃癌ＣＤ４４的表达，有助于对胃癌生物学行为的了解及对患者预后的判断。
Objective To study the expression of CD44 in gastric carcinoma and its prognostic significance. Methods Immunohistochemical SP method was used to study the expression of CD44 in 110 surgical specimens of gastric cancer. Results The positive rate of CD44 expression in primary gastric cancer was 53.64% (59/110). The expression of CD44 was positively correlated with the depth of gastric cancer infiltration, regional lymph node metastasis, and the progress of clinical pathological staging of gastric cancer (P< 0.05). The 3-year and 5-year survival rates of CD44-negative patients were significantly higher than those of CD44-positive patients (P<0.01). Conclusion CD44 may be involved in the invasion and lymph node metastasis of gastric cancer. The prognosis of CD44 negative patients is good. Detecting the expression of CD44 in gastric cancer is helpful for understanding the biological behavior of gastric cancer and judging the prognosis of patients.