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儿童哮喘近10年来其发病率与病死率有增加趋势。由于其病因多,机制复杂,病情轻重不等,治疗方法也不尽相同。本文就其药物治疗作一简要评价。 1 茶碱类 通过抑制cAMP分解,间接提高气道平滑肌细胞内cAMP浓度而发挥解痉平喘作用。除常用的茶碱、氨茶碱外,新一代衍生物如3-丙基黄嘌呤,对腺苷受体无拮抗作用,副作用少。研究表明,茶碱是唯
Childhood asthma in the past 10 years the incidence and mortality have an increasing trend. Because of its etiology, complex mechanisms, severity varies, treatment methods are not the same. This article on its medical treatment for a brief evaluation. 1 Theophylline exerts antispasmodic and antiasthmatic effects by inhibiting the cAMP breakdown and indirectly increasing cAMP concentration in airway smooth muscle cells. In addition to commonly used theophylline, aminophylline, a new generation of derivatives such as 3-propylxanthine, adenosine receptor antagonism, side effects. Research shows that theophylline is the only