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中国药典收载的2％盐酸利多卡因注射液含量测定方法采用有机碱盐常用的提取中和法,在碱性条件下,用氯仿分次提取利多卡因,提取液蒸干后,因游离碱在水中溶解度小,须加入过量硫酸标准液生成硫酸利多卡因,再以氢氧化钠标准液回滴定,此法操作繁琐、费时。本文采用直接滴定的方法,结果准确,改
Determination of 2% lidocaine hydrochloride injection contained in Chinese Pharmacopoeia Using the method of extraction and neutralization commonly used in organic alkali salts, under the alkaline conditions, the extraction of lidocaine by fractional extraction with chloroform, Alkali solubility in water is small, to be added excess sulfuric acid standard solution to generate lidocaine sulfate, then sodium hydroxide standard solution titration, this method of operation cumbersome and time-consuming. In this paper, the direct titration method, the result is accurate, change