论文部分内容阅读
前言聚醚类抗生素(Polyether Antibiotics)或称离子载体抗生素(Ionophorous Antibiotics),是七十年代中期发展起来的具有阳离子载体性质的微生物次级代谢产物,为拥有环醚结构系统的单羧基化合物,化学结构十分特殊。聚醚类抗生素由Westley于1974年首先命名至今已分离出40多个聚醚类抗生素。近10年来,分子生物学的发展,对研究发展这类抗生素起了促进作用。离子载体抗生素作为活动载体(Moble Carriers)和金属离子形成稳定的亲水性复合物,带着这些离子跨过天然的或人工合成膜的研究工作越来越多。它对禽畜球虫病,毒浆原虫的显著杀虫活性也引人瞩目。目前国外已有莫恩菌素(Monensin)、盐霉素(Salinomycin)、拉沙里
Introduction Polyether Antibiotics, or Ionophorous Antibiotics, are secondary metabolites of cationic carrier-type organisms developed in the mid-1970s. They are monocarboxylic compounds possessing a cyclic ether system, The structure is very special. Polyether antibiotics were first named by Westley in 1974 and more than 40 polyether antibiotics have been isolated so far. In the past 10 years, the development of molecular biology has played a catalytic role in the research and development of such antibiotics. Ionophores Antibiotics act as stable hydrophilic complexes as Moble Carriers and metal ions, and more and more work is being carried out with these ions across natural or synthetic membranes. It is also notable for its significant insecticidal activity against coccidiosis and virulent protozoa. At present, there are foreign Monensin, Salinomycin, Lassari