论文部分内容阅读
青霉素除了可引起过敏反应和免疫性副作用外,对人类毒性很低。无肾功能衰竭者,大剂量(如每天静注1亿单位)会产生惊厥和昏迷;肾功能衰竭或血脑屏障受损时(心肺旁路或脑膜炎)较小的剂量也会产生同样症状。本文报道6例患者因全身性应用青霉素G引起凝血障碍。1例3周前局部麻醉拔牙后并发颌下脓肿发热(39℃),用先锋霉素及庆大霉素治疗热退,但发生急性肾功能衰竭,颌下可触及有波动感的脓肿,当时怀疑厌氧菌感染,乃注射青霉素G1,000万单位/天,
In addition to penicillin can cause allergic reactions and immune side effects, the human toxicity is very low. In the absence of renal failure, high doses (eg, 100 million intravenous infusions) produce seizures and coma; the same symptoms occur with lower doses of renal failure or impaired blood-brain barrier (cardiopulmonary bypass or meningitis) . This article reports 6 cases of systemic coagulation disorders caused by penicillin G. One case had local submandibular abscess fever (39 ℃) after local anesthesia 3 weeks before tooth extraction, treated with Vanguard ADM and gentamicin, but had acute renal failure and submaxillary touch with fluctuating abscess. At that time, Suspected anaerobic infections, penicillin G1000 million units / day,