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目的用２４ｈ动态血压监测方法评价可乐定透皮控释贴片（Ｃ－ＴＴＳ）的降压疗效。方法轻中度原发性高血压患者１５例，平均年龄５２．１±８．４岁。用安慰剂贴片２周后，改用一贴Ｃ－ＴＴＳ（含量２．５ｍｇ／片，面积２．２７ｃｍ２，日释放量０．１ｍｇ），７天更换贴片。结果６例患者仅用一贴Ｃ－ＴＴＳ血压降至目标血压，１２例患者使用１～３贴血压得到控制，总有效率为８０％。治疗后白天、夜间及２４ｈ平均舒张压均明显降低（Ｐ＜０．０５）；白天、夜间及２４ｈ的收缩压和舒张压负荷明显降低（Ｐ＜０．０１）。结论Ｃ－ＴＴＳ能降低２４ｈ血压，作用时间可达７天，治疗依从性好。
Objective To evaluate the antihypertensive effect of clonidine transdermal controlled release patch (C-TTS) with 24-hour ambulatory blood pressure monitoring. Methods 15 patients with mild to moderate essential hypertension, mean age 52.1 ± 8.4 years. After 2 weeks with placebo, a patch of C-TTS (content 2.5mg / tablet, area 2.27cm2, daily release 0.1mg) was switched to patch for 7 days. Results Six patients only had one C-TTS pressure drop to the target blood pressure. Twelve patients were controlled with 1-3 blood pressure, with a total effective rate of 80%. The mean diastolic pressure at daytime, nighttime and 24h after treatment were significantly decreased (P <0.05). The systolic and diastolic blood pressure during day, night and 24h were significantly decreased (P <0.01). Conclusion C-TTS can reduce blood pressure 24h, the role of up to 7 days, good compliance treatment.