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目的：探讨核仁组成区嗜银蛋白（ＡｇＮＯＲｓ），ｐ５３蛋白在胶质细胞增生和胶质瘤中的表达。方法：运用免疫组化和形态半定量技术，对胶质细胞增生和星形细胞瘤分别标记ＡｇＮＯＲｓ（３７例），ｐ５３蛋白（３３例）的表达。结果：ＡｇＮＯＲｓ，ｐ５３蛋白在胶质细胞增生和Ⅰ级星形细胞瘤以及Ⅱ、Ⅲ、Ⅳ级星形细胞瘤中的表达存在差异性，各组间统计学处理Ｐ＜０．０１，差异有显著性。结论：ＡｇＮＯＲｓ、ｐ５３蛋白可作为鉴别胶质细胞增生和Ⅰ级星形细胞瘤有用的参考指标，两者表达随着星形细胞瘤级别增加而增强，具有正相关性，能较好地反映星形细胞瘤的恶性程度
Objective: To investigate the expression of AgNORs and p53 protein in glial cell proliferation and glioma. METHODS: Immunohistochemistry and morphometric semi-quantitative techniques were used to label AgNORs (37 cases) and p53 protein (33 cases) expression in glioblastoma and astrocytoma, respectively. Results: The expression of AgNORs and p53 protein in glial cell proliferation and grade I astrocytoma and grade II, III and IV astrocytoma were different. Statistical analysis was performed between groups P<0.01. Significant. Conclusions: AgNORs and p53 proteins can be used as useful reference markers for the identification of glial cell proliferation and grade I astrocytoma. The expression of AgNORs and p53 protein increases with the increase of astrocytoma grade, and has a positive correlation and can reflect the stars better. Malignant tumors