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目的：研究增液润燥汤对SS模型鼠颌下腺IL-23的影响，探究本方治疗SS的机制。方法60只BALb/c小鼠，随机法均分为：正常组，模型组，本方低、中、高组，西药组；免疫诱导法制备SS模型；ELISA法检测IL-23水平。结果模型组IL-23比正常组显著升高；各治疗组IL-23比模型组降低，差别均有统计学意义(P<0.05)。结论本方能降低SS模型鼠颌下腺IL-23水平，通过降低IL-23水平，抑制病灶炎症反应，减轻唾液分泌腺损伤。“,”Objective To explore the mechanism of Zengye Runzao decoction treating SS by studying its ef ect on IL-23 in the submandibular gland of Sj?gren rats. Methods 60 BALB/c mice were evenly randomized into 6 groups:the blank group, the model group, three groups of Zengye Runzao decoction, the group of Total Glucosides of White Paeony Capsules. Model was made by inducing autoimmunity. The level of IL-23was tested by ELISA. Results Compared withblank group, the level of IL-23inmodel group increased;The level of IL-23intreatment groups decreased compared withmodel group, both dif erenceshad statistical significance( <0.05). Conclusion Zengye Runzao decoction can decrease the level of IL-23 so thatinflammatory is control ed, and the function ofdamaged gland is protected.