论文部分内容阅读
目的分析河北汉族成年人群中白细胞介素10(interleukin-10,IL-10)rs1800871、rs1800872基因多态性与幽门螺杆菌(Helicobacter pylori,H.pylori)感染的关系,探讨IL-10 rs1800871、rs1800872多态性与H.pylori临床易感性的关系。方法病例组H.pylori感染患者116例,对照组87例纳入研究,留取外周静脉血提取DNA,直接测序法对IL-10 rs1800871、rs1800872 SNP进行基因分型,统计分析各位点多态性与H.pylori临床易感性关系。结果IL-10 rs1800871、rs1800872基因多态性在病例组与对照组等位基因、基因型之间的分布差异均无统计学意义(P>0.05)。结论 IL-10 rs1800871、rs1800872基因多态性与H.pylori易感性可能不相关。
Objective To analyze the association between polymorphisms of rs1800871, rs1800872 and Helicobacter pylori (H.pylori) infection in adult population of Han nationality in Hebei province and to explore the relationship between IL-10 rs1800871, rs1800872 Relationship between polymorphism and clinical susceptibility to H.pylori. Methods One hundred and sixty-six patients with H.pylori infection and 87 control subjects were enrolled in the study. DNA was extracted from peripheral venous blood and genotyped by IL-10 rs1800871 and rs1800872 SNPs. The polymorphisms H.pylori clinical susceptibility relationship. Results The polymorphisms of IL-10 rs1800871 and rs1800872 were not significantly different between the case group and the control group in allele and genotype (P> 0.05). Conclusion The polymorphisms of IL-10 rs1800871 and rs1800872 may not be related to the susceptibility to H.pylori.