叶绿酸对氯化汞诱导的小鼠染色体断裂的影响

• 作 者: 朱心强
• 出 处: 国外医学(卫生学分册)
• 发表日期: 1992年03期
• 关键词: 染色体断裂 骨髓染色体 阴性对照 Swiss 染色单体裂隙 诱变作用 细胞百分率 染色体畸变 环磷酞胺 染色单体断裂

为了研究叶绿酸 (其铜钠盐,简称CHY)对氯化汞(HgCl_2)诱导的骨髓染色体损伤作用的影响,选用纯种雄性Swiss小鼠(8～10wk,25～28g),分为12组,每组5只,分别进行如下处理:(1) 阴性对照 (给蒸馏水);(2)阳性对照 (给环磷酰胺);(3) 单给CHY(1.5mg/kg);4～6组分别单给HgCl_23.0,6.0,12.0mg/kg;7～9组先给CHY(1.5mg/kg),2小时后分別给HgCl_23.0,6.0,12.0mg/kg;

In order to investigate the effect of chlorophyllin (CHY) on chromosomal damage of bone marrow induced by HgCl_2, purebred male Swiss mice (8 ~ 10wk, 25 ~ 28g) were divided into 12 groups Group, with 5 in each group, were treated as follows: (1) Negative control (to distilled water); (2) Positive control to cyclophosphamide; (3) CHY alone Groups were given single HgCl_23.0,6.0,12.0 mg / kg; 7 to 9 groups given CHY (1.5mg / kg), respectively, 2 hours later HgCl_23.0,6.0,12.0 mg / kg;