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目的分析老年耐多药肺结核病患者肺部感染病原菌分布及感染危险因素,指导控制预防老年耐多药肺结核病发生肺部感染的临床治疗,降低感染率。方法选取2009-2013年老年耐多药肺结核患者合并肺部感染230例,分离培养病原菌并进行药敏试验,研究老年耐多药肺结核病患者合并肺部感染的危险因素,采用SPSS13.0进行统计处理。结果共发生肺部感染的患者72例,感染率为31.30%,共分离得77株病原菌,其中革兰阳性菌29株占37.66%,革兰阴性菌40株占51.95%,真菌8株占10.39%;合并肺部感染的危险因素主要包括:患者年龄大、住院时间长、肺结核病程长、合并有其他疾病、进行侵入性操作以及为预防性应用抗菌药物。结论老年耐多药肺结核患者肺部感染的发生率高,临床应采取措施控制老年耐多药肺结核患者肺部感染的发生。
Objective To analyze the distribution of pulmonary pathogens and the risk factors of infection in elderly patients with multidrug-resistant pulmonary tuberculosis and to guide the prevention and treatment of lung infections in elderly multi-drug resistant pulmonary tuberculosis and to reduce the infection rate. Methods A total of 230 elderly patients with MDR-TB were selected from 2009 to 2013. Pathogenic bacteria were isolated and cultured and susceptibility test was conducted to study the risk factors of pulmonary infection in elderly MDR-TB patients. SPSS 13.0 was used for statistics deal with. Results A total of 72 patients with pulmonary infection were infected with the infection rate of 31.30%. 77 pathogens were isolated, of which 29 were Gram-positive bacteria, 37.66% were Gram-negative bacteria, 40 strains were Gram-negative bacteria, 51.95% were Gram-negative bacteria and 10.39 %; The risk factors for pulmonary infection include: older patients, hospitalization for a long duration of tuberculosis, combined with other diseases, invasive procedures and the preventive use of antimicrobial agents. Conclusion The incidence of pulmonary infection in elderly MDR-TB patients is high, so clinical measures should be taken to control the incidence of pulmonary infections in elderly MDR-TB patients.