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2型糖尿病共病抑郁 (type 2 diabetes comorbid depression, T2DD)使患者自我管理和依从性变差，增加社会负担。然而，T2DD的病理生理机制尚未完全阐明，目前大部分研究主要集中在下丘脑-垂体-肾上腺轴、免疫炎症系统、胰岛素抵抗的作用以及T2DD的神经影像学改变方面。因此，本文就当前T2DD的研究现状予以综述，以了解其最新研究进展。“,”Type 2 diabetes often comorbid with depression (T2DD),leading to poor compliance,poor self-management and increasing social burden.However,the underlying pathophysiological mechanism has not been fully elucidated.Numerous studies mainly focused on the hypothalamic-pituitary-adrenalaxis,immune inflammatory system,insulin resistance and neuroimaging changes of T2DD.Thus the present review will summarize the major recent advances in current understanding of T2DD.