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头孢三嗪是一种新型的头孢菌素,体外试验证明对沙门氏菌具有良好的抗菌活性。由于头孢三嗪能渗入组织特别是细胞内,因此对细胞内伤寒杆菌可能具有抗菌作用。作者按随机数字表编组法将63例经细菌学证实的伤寒病人分为两组,比较头孢三嗪与氯霉素的治疗效果。材料氯霉素组31例,剂量为每日60mg/kg,分4次口服或静滴,退热后减为40mg/kg,疗程14天。头孢三嗪组32例,成人剂量为每日3～4g,儿童75mg/kg,1次静脉滴注,疗程7天。
Ceftriaxone is a new type of cephalosporin, in vitro tests showed that Salmonella has good antibacterial activity. As ceftriaxone can penetrate into tissues, especially intracellular, it may have antibacterial effect on intracellular typhoid bacillus. 63 cases of bacteriologically confirmed typhoid fever patients were divided into two groups according to the random number table marshaling method to compare the therapeutic effects of ceftriaxone and chloramphenicol. Materials Chloramphenicol group of 31 cases, the daily dose of 60mg / kg, 4 times orally or intravenously, after fever reduced to 40mg / kg, treatment for 14 days. 32 cases of ceftriaxone, adult dose of 3 ~ 4g daily, children 75mg / kg, 1 intravenous infusion, treatment for 7 days.