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【目的】合成具有抗菌活性的新结构硫脲类化合物。【方法】通过α-异硫氰酸酯中间体与不同伯胺缩合合成硫脲类化合物,利用质谱、核磁分析鉴定结构,并评价其抑菌活性。【结果】合成了六种新结构的硫脲类化合物以及一种α-异硫氰酸酯类衍生物,对几种代表性病原细菌和真菌具有抑菌活性。其中,硫脲类化合物对新型隐球菌的抑制效果较为显著。【结论】通过不同结构硫脲类衍生物的合成,可能筛选出具有抑制新型隐球菌等致病菌的前体化合物。
【Objective】 A new thiourea compound with antibacterial activity was synthesized. 【Method】 Thiourea compounds were synthesized through the condensation of α-isothiocyanate intermediates with different primary amines. Their structures were identified by mass spectrometry and nuclear magnetic resonance (NMR), and their antibacterial activities were evaluated. 【Result】 Six new thiourea compounds and one α-isothiocyanate derivatives were synthesized. They have antibacterial activity against several representative pathogenic bacteria and fungi. Among them, thiourea compounds have a significant inhibitory effect on Cryptococcus neoformans. 【Conclusion】 Through the synthesis of thiourea derivatives with different structures, it is possible to screen out the precursor compounds that inhibit pathogenic bacteria such as Cryptococcus neoformans.