Human papillomavirus-associated diseases and cancers

• 作 者: Lan Yang Jianbo Zhu Xiaoyue Song Yan Qi Xiaobin Cui Feng Li
• 机 构: Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi Univers
• 出 处: Oncology and Translational Medicine
• 发表日期: 2015年03期
• 关键词: papillomavirus papilloma replication maintain competent esophageal differentiate

Human papillomaviruses(HPVs) have been detected in cervical cancer cells and skin papilloma cells, which have a variety of types, including low-risk and high-risk types. HPV genome replication requires the host cell’s DNA synthesis machinery, and HPVs encode proteins that maintain differentiated epithelial cells in a replication-competent state. HPV types are tissue-specific and generally produce different types of lesions, either benign or malignant. This review examines different HPV types and their associated diseases and presents therapeutic options for the treatment of HPV-positive diseases.

Human papillomaviruses (HPVs) have been detected in cervical cancer cells and skin papilloma cells, which have a variety of types, including low-risk and high-risk types. HPV genome replication requires the host cell’s DNA synthesis machinery, and HPVs encode proteins that maintain differentiated epithelial cells in a replication-competent state. HPV types are tissue-specific and generally produce different types of lesions, either benign or malignant. This review examines different HPV types and their associated diseases and presents therapeutic options for the treatment of HPV- positive diseases.