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应用抗铁蛋白多抗、抗铁蛋白H、L亚基单抗和流式细胞测定技术,对23例手术切除的肝癌及癌周肝组织所含铁蛋白及H、L亚基进行定量免疫荧光研究,发现:1.癌周铁蛋白及H、L亚基与正常肝相差无显著性意义(p>0.05)。2.癌组织铁蛋白及其亚基均比癌周低(p<0.001)。3.癌、癌周的L亚基高于H亚基(p<0.001),L、H亚基有重要相关(癌:r=0.8,p<0.001;癌周:r=0.42,p<0.05)。4.有无肝硬化不影响肝癌及癌周铁蛋白及亚基含量。
Application of anti-ferritin multi-antibody, anti-ferritin H, L subunit monoclonal antibody and flow cytometry technique, quantitative immunofluorescence of ferritin and H, L subunits in 23 cases of hepatic carcinoma and hepatic tissue The study found that: 1. There was no significant difference between the serum ferritin and H and L subunits and normal liver (p>0.05). 2. The tumor tissue ferritin and its subunits were all lower than the cancer week (p<0.001). 3. The L subunit of cancer and pericancerous lesions was higher than that of H subunit (p<0.001), and there was an important correlation between L and H subunits (carcinoma: r=0.8, p<0.001; cancerous week: r=0.42, p<0.05. ). 4. The presence or absence of cirrhosis did not affect the contents of hepatic ferritin and peritumoral ferritin and subunits.