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目的观察香菇C91-3菌丝发酵蛋白对荷瘤小鼠免疫系统的作用。方法昆明小鼠24只,S180瘤细胞荷瘤建立动物模型,随机平均分为3组:香菇C91-3菌丝发酵蛋白治疗组、环磷酰胺治疗组、生理盐水对照组。观察香菇C91-3菌丝发酵蛋白对荷瘤小鼠NK细胞活性、淋巴细胞转化率、IFN-γ和TNF-α等免疫指标的影响。结果香菇C91-3菌丝发酵蛋白能够显著提高治疗组小鼠的NK细胞活性、淋巴细胞转化率和血清中IFN-γ和TNF-α的含量。结论香菇C91-3菌丝发酵蛋白能够显著提高荷瘤小鼠免疫系统的活性。
Objective To observe the effect of Mushroom C91-3 mycelium fermenting protein on immune system of tumor-bearing mice. Methods Twenty-four Kunming mice and S180 tumor-bearing mice were randomly divided into 3 groups: Mushroom C91-3 mycelium fermented protein treatment group, cyclophosphamide treatment group and saline control group. To observe the effect of Mushroom C91-3 mycelium fermenting protein on immune function such as NK cell activity, lymphocyte transformation rate, IFN-γ and TNF-α in tumor-bearing mice. Results Mushroom C91-3 mycelium fermentation protein can significantly improve the NK cell activity, lymphocyte transformation rate and serum levels of IFN-γ and TNF-α in the treated mice. Conclusion Mushroom C91-3 mycelium fermentation protein can significantly improve the activity of tumor-bearing mice immune system.