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目的探讨去分化软骨肉瘤的临床表现、影像学、病理学特点。方法选取2002—2014年间确诊去分化软骨肉瘤12例,对其临床表现、放射学改变、病理形态学资料进行回顾性分析。结果男性8例,女性4例,年龄21~63岁,平均48岁,发病部位为股骨4例、胫骨3例、肱骨2例、骨盆1例、肩胛骨1例、掌骨1例;主要临床症状为疼痛、肿胀,局部可触及肿块,1例患者因病理性骨折就诊。去分化软骨肉瘤表现为双重形态特征的恶性肿瘤,中央型多于周围型,组织学由分界清楚的高分化软骨性肿瘤和高级别间变性肉瘤构成。结论去分化软骨肉瘤较少见,结合影像及组织病理形态特征对去分化软骨肉瘤的诊断及治疗有重要意义。
Objective To investigate the clinical manifestations, imaging and pathological features of dedifferentiated chondrosarcoma. Methods Twelve patients with dedifferentiated chondrosarcoma diagnosed between 2002 and 2014 were retrospectively analyzed. The clinical manifestations, radiological changes and pathomorphological data were retrospectively analyzed. Results There were 8 males and 4 females, aged from 21 to 63 years old (average 48 years). The incidence sites were 4 femur, 3 tibia, 2 humerus, 1 pelvis, 1 scapula and 1 metacarpal. The main clinical symptoms were Pain, swelling, local palpable mass, 1 patient due to pathological fractures. Dedifferentiated chondrosarcoma is a malignant tumor characterized by a double morphological appearance. The central type is more peripheral than that of the peripheral type. Histology consists of well-demarcated well-differentiated cartilage tumors and high-grade, atypical sarcomas. Conclusion Dedifferentiated chondrosarcomas are rare, and the combined imaging and histopathological features are of great significance in the diagnosis and treatment of dedifferentiated chondrosarcoma.