论文部分内容阅读
本文介绍反复肌肉注射氨噻肟头孢菌素(Cefotaxime)的药物动力学研究情况。8名健康志愿者参加这项研究,他们的年龄从25岁到32岁(平均为27岁),体重从64公斤到87公斤(平均为74公斤)。所有的受试者在试验开始前一天及开始后每天作物理及生化检查,包括全血计数、库姆斯氏试验、尿分析、肌酸酐廓清率、肌酸磷酸激酶(CPK)、谷草转氨酶(GOT)及谷丙转氨酶(GPT)试验。5天中每8小时肌肉注射1克药物,第
This article describes the pharmacokinetics of repeated intramuscular injection of cefotaxime. Eight healthy volunteers were enrolled in the study. Their ages ranged from 25 to 32 years (average 27 years) and ranged from 64 kg to 87 kg (an average of 74 kg). All subjects performed daily physical and biochemical tests, including whole blood count, Coombs test, urinalysis, creatinine clearance rate, creatine phosphokinase (CPK), aspartate aminotransferase GOT) and alanine aminotransferase (GPT) test. 5 grams every 8 hours intramuscular injection of 1 gram of drug, the first