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目的:探讨静脉滴注异舒吉(单硝酸异山梨醇酯)治疗冠心病心绞痛的临床疗效。方法:将2010年1月至2011年12月我院确诊的冠心病心绞痛患者90例随机、双盲分为两组,对照组40例,采用硝酸甘油治疗;治疗组50例,采用异舒吉治疗,比较两组的临床疗效及不良反应发生率。结果:治疗组和对照组的临床疗效都较治疗前有显著改善,但治疗组的疗效显著优于对照组(P<0.05);治疗组出现胃肠道不适、恶心、呕吐者2例,对照组出现面红、头晕或头痛者5例,对症治疗后均缓解。结论:静脉滴注异舒吉治疗冠心病心绞痛的疗效确切,临床不良反应小,值得临床广泛使用。
Objective: To investigate the clinical effect of intravenous Isosorbide (isosorbide mononitrate) in the treatment of angina pectoris of coronary heart disease. Methods: From January 2010 to December 2011, 90 patients with coronary heart disease and angina pectoris diagnosed in our hospital were randomly divided into two groups, control group (n = 40) and nitroglycerin treatment group (n = 50) The clinical efficacy and the incidence of adverse reactions in both groups were compared. Results: The clinical curative effect of the treatment group and the control group was significantly improved compared with that before treatment, but the curative effect of the treatment group was significantly better than that of the control group (P <0.05); 2 cases of gastrointestinal discomfort, nausea and vomiting were found in the treatment group, Group appeared red, dizziness or headache in 5 cases, symptomatic treatment were relieved. Conclusion: Intravenous Isosorbide is effective in treating angina pectoris of coronary heart disease and its clinical adverse reaction is small. It is worth widely used in clinic.