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非小细胞肺癌(NSCLC)是危害人类生命最常见的恶性肿瘤之一。表皮生长因子受体(EGFR)基因突变及过表达与NSCLC的发生、发展、侵袭等密切相关。EGFR突变是最有前途的NSCLC靶向治疗分子机制之一,EGFR检测指导选择合适的患者进行靶向治疗成为靶向治疗成败的关键。本文就EGFR检测方法及其在NSCLC中的应用作一综述。
Non-small cell lung cancer (NSCLC) is one of the most common malignancies that endanger human life. Epidermal growth factor receptor (EGFR) gene mutation and overexpression are closely related to the occurrence, development and invasion of NSCLC. EGFR mutation is one of the most promising molecular mechanisms of targeted therapy in NSCLC. EGFR test guide the selection of appropriate patients for targeted therapy as the key to the success or failure of targeted therapy. This article reviews the EGFR detection method and its application in NSCLC.