论文部分内容阅读
目的：检测脑梗塞并发多器官功能衰竭（ＭＯＦ）患者血清肿瘤坏死因子（ＴＮＦ）的含量变化并探讨其意义。方法：单纯急性脑梗塞患者（ＡＣＩ组）２１例，脑梗塞并发多器官功能衰竭患者（ＭＯＦ组）２４例（其中伴上消化道出血１１例，心功能衰竭７例，肾功能衰竭６例）。采用放射免疫方法检测２组患者血清ＴＮＦ的含量。结果：脑梗塞并发ＭＯＦ组ＴＮＦ含量〔（２．４７±０．３９）μｇ／Ｌ〕明显高于ＡＣＩ组〔（１．８９±０．２４）μｇ／Ｌ〕，Ｐ＜０．０１。脑梗塞并发ＭＯＦ组中各亚组间ＴＮＦ〔上消化道出血组（２．５３±０．４３）μｇ／Ｌ，心功能衰竭组（２．０１±０．２８）μｇ／Ｌ，肾功能衰竭组（２．４１±０．３２）μｇ／Ｌ〕差异显著（Ｐ均＜０．０１），尤以上消化道出血组升高明显。结论：ＴＮＦ参与了脑梗塞并发上消化道出血的发病；监测ＴＮＦ变化有助于对脑梗塞并发ＭＯＦ患者的病情观察和预后估计。
Objective: To detect the changes of serum tumor necrosis factor (TNF) in patients with cerebral infarction complicated with multiple organ failure (MOF) and to explore its significance. Methods: Twenty-one patients in acute ACI group, 24 patients in cerebral infarction complicated with multiple organ failure (MOF group) (11 cases with upper gastrointestinal bleeding, 7 cases with heart failure and 6 cases with renal failure) . Radioimmunoassay was used to detect serum TNF levels in two groups. Results: The TNF level in cerebral infarction complicated with MOF was (2.47 ± 0.39) μg / L, significantly higher than that in ACI group (1.89 ± 0.24) μg / L, P <0.01. The levels of TNF (2.53 ± 0.43) μg / L, 2.01 ± 0.28 μg / L, renal failure (2.41 ± 0.32) μg / L〕 (P <0.01), especially in the upper gastrointestinal bleeding group increased significantly. CONCLUSION: TNF participates in the pathogenesis of upper gastrointestinal bleeding in patients with cerebral infarction. Monitoring the changes of TNF may be helpful for the observation and prognosis of patients with cerebral infarction complicated with MOF.