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作者报道应用胰高糖素及胰岛素静脉滴注治疗急性重症酒精性肝炎的随机临床试验结果。病例标准包括饮酒后有发热,黄疸和肝肿大,伴有血清胆红素>5mg%、SGOT>SGPT、凝血酶原<50%以及白细胞计数增高至12,000/mm~3。35例随机抽样,分成2组.治疗组13例,对照组17例。两组的各项临床指标均相似.治疗组病人用10%葡萄糖溶液持续滴注,包括胰岛素每小时2U、胰高糖索每小时0.2mg、滴注速度40ml/h,持续应用2周,对照组单用10%葡萄糖40ml/h,也持续应用2周。住院至分组治疗的间隔时间:治疗组为7.6±1.8天,对照组为6.4±2.5天。每组有2例病人,未完成试验程序,他们的结果被除外。治疗组中25%病人死
The authors report the results of a randomized clinical trial of glucagon and insulin in the treatment of acute severe alcoholic hepatitis. Case histories included fever, jaundice and hepatomegaly following alcohol consumption, with serum bilirubin> 5 mg%, SGOT> SGPT, prothrombin <50%, and leukocyte count increased to 12,000 / mm3.35 randomized, Divided into two groups: 13 cases in the treatment group and 17 cases in the control group. The clinical parameters of the two groups were similar.The patients in the treatment group were treated with 10% glucose solution, including 2U per hour of insulin, 0.2mg per hour of high glucose and 40ml / h of drip infusion for 2 weeks, Group with 10% glucose 40ml / h, also continued to apply for 2 weeks. The hospital-to-group treatment interval was 7.6 ± 1.8 days in the treatment group and 6.4 ± 2.5 days in the control group. Two patients in each group did not complete the test procedure and their results were excluded. 25% of patients died in the treatment group