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目的探讨干扰素联合炎琥宁治疗小儿手足口病的临床效果。方法 60例手足口病患儿,随机分成A、B、C组三组,每组20例。A组患儿给予单一干扰素治疗,B组患儿给予单一炎琥宁治疗,C组患儿给予干扰素联合炎琥宁治疗;对比分析三组患儿的临床疗效。结果 A组、B组患儿的临床治疗总有效率、退烧时间、口腔溃烂愈合时间和住院时间比较差异无统计学意义(P>0.05)。C组患儿的临床治疗总有效率、手足疱疹消退时间、退热时间、口腔溃烂愈合时间和住院时间显著优于A组、B组,比较差异均有统计学意义(P<0.05)。结论在对小儿手足口病患儿进行治疗时,干扰素联合炎琥宁治疗具有显著的疗效,能有效改善患儿的临床症状,值得临床推广和应用。
Objective To investigate the clinical efficacy of interferon combined with metronidazole in the treatment of hand-foot-mouth disease in children. Methods Sixty children with hand-foot-mouth disease were randomly divided into three groups (A, B and C), 20 in each. A group of children given a single interferon treatment, B group given a single Yan Hu Ning treatment, C group given interferon and Yan Hu Ning treatment; comparative analysis of the clinical efficacy of three groups of children. Results The total effective rate of clinical treatment, fever relief time, healing time of oral ulcer and hospital stay in group A and group B were not statistically significant (P> 0.05). The total effective rate of clinical treatment of C group, the elimination time of herpes simplex and herpes zoster, the time of fever, the healing time of oral ulceration and hospital stay were significantly better than those in group A and group B (P <0.05). Conclusion In the treatment of children with hand-foot-mouth disease in children, interferon combined with the treatment of Yan Hu Ning has a significant effect, can effectively improve the clinical symptoms of children, is worthy of clinical promotion and application.