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目的 观察化疗间歇期行乳腺癌骨转移灶短程放疗止痛的疗效。方法 1991年 1月至 2 0 0 0年 10月 ,共32例乳腺癌骨转移患者接受化疗间歇期短程放疗止痛 (化放组 ) ,将同期单纯接受化疗的乳腺癌骨转移患者与化放组病例进行配对 (单化组 ) ,进行回顾性配对分析 ,比较两组止痛疗效及毒副作用。结果 化疗组止痛总有效率为 93.8% ,单化组为 46 .9% ,两组比较 ,差异非常显著 (P <0 .0 1) ;两组病例毒副反应主要以骨髓抑制为主 ,化放组Ⅰ～Ⅱ度及Ⅲ～Ⅳ度白细胞减少发生率均高于单化组 ,两组比较 ,差异无显著性 (P >0 .0 5 )。结论 化疗间歇期行短程放疗止痛 ,对乳腺癌骨转移灶的疼痛具有良好的止痛效果 ,治疗时间短 ,且不明显增加毒副作用。
Objective To observe the curative effect of short-term radiotherapy and analgesia of bone metastasis of breast cancer during intermittent chemotherapy. Methods From January 1991 to October 2000, a total of 32 patients with breast cancer with bone metastasis received short-term chemotherapy and analgesia (chelation group) during the intermittent chemotherapy period. Patients with bone metastasis of breast cancer who underwent simple chemotherapy and those treated with chemotherapy alone The patients were matched (single group), retrospective paired analysis, analgesic efficacy and side effects were compared between the two groups. Results The total effective rate of pain relief was 93.8% in the chemotherapy group and 46.9% in the chemotherapy group, with significant difference between the two groups (P <0.01). The main adverse reactions of the two groups were mainly myelosuppression, The incidence of leukopenia in grade Ⅰ ~ Ⅱ and grade Ⅲ ~ Ⅳ of the treated group were higher than those in the simple group. There was no significant difference between the two groups (P> 0.05). Conclusion Intermittent chemotherapy with short-range radiotherapy and analgesia has a good analgesic effect on the pain of bone metastases in breast cancer. The treatment time is short and the side effects are not obviously increased.