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目的:研究Survivin、Livin和NF-kB在大肠癌中的表达以及相互关系。方法:择于2014年2月至2015年3月于我院就医的大肠癌病患34例,作为本次研究的研究组,该组所有病患均通过入院前确诊,满足大肠癌病理诊断标准,然后将同期进行健康体检的34例普通人作为本次研究的对照组,分析Survivin、Livin和NF-kB等表达情况及彼此关联性,并且计算阳性率进行组间对比。结果:根据本次研究结果显示,在表达情况对比方面,研究组34例病患无论在Survivin、Livin和NF-kB等指标的阳性率方面均显著大于对照组,且各项指标呈现两两相关性,以上组间数据对比存在显著差异,符合统计学意义(P<0.05)。结论:大肠癌病患的Survivin、Livin和NF-kB指标明显高于一般健康人的相关指标,因而可以作为该病临床确诊的主要依据。
Objective: To investigate the expression of Survivin, Livin and NF-kB in colorectal carcinoma and their correlation. Methods: A total of 34 patients with colorectal cancer who were admitted to our hospital from February 2014 to March 2015 were enrolled in this study. All patients in this group were diagnosed before admission to meet the criteria for pathological diagnosis of colorectal cancer Then, 34 normal people who took part in the same period of physical examination were taken as the control group to analyze the expression of Survivin, Livin and NF-kB and their correlation with each other, and the positive rate was calculated for comparison between groups. Results: According to the results of this study, 34 cases of study group were significantly higher than those of control group in terms of the positive rate of Survivin, Livin and NF-kB, and the indicators showed a pairwise correlation Sex, the data between the above groups were significantly different, in line with statistical significance (P <0.05). Conclusion: Survivin, Livin and NF-κB in patients with colorectal cancer were significantly higher than those in normal healthy people, and could be used as the main basis for clinical diagnosis.