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为探讨妇女白细胞介素－６（ＩＬ－６）及雌激素水平的变化对骨丢失的影响，本文采用四甲基偶氮唑盐微量酶反应比色法（ＭＴＴ）检测青年妇女、围绝经妇女及绝经后妇女的血清ＩＬ－６活性，用放免法检测血清雌二醇（Ｅ２）水平，双能Ｘ线吸收仪测定Ｌ２～４的骨密度（ＢＭＤ）。结果表明：绝经后妇女的血清ＩＬ－６活性明显升高，但血清Ｅ２水平却显著低于青年妇女与围绝经妇女（Ｐ＜０．０１），ＢＭＤ也显著低于青年妇女与围绝经妇女（Ｐ＜０．０１）。相关分析显示，ＩＬ－６与ＢＭＤ呈负相关（ｒ＝－０．７２４，Ｐ＜０．０５），与Ｅ２呈负相关（ｒ＝－０．７５９，Ｐ＜０．０１），Ｅ２与ＢＭＤ呈正相关（ｒ＝０．６６０，Ｐ＜０．０１）。提示，Ｅ２缺乏及其所致的ＩＬ－６水平升高在绝经后骨质疏松的发病机制中起重要作用。
In order to investigate the effect of interleukin-6 (IL-6) and estrogen levels on bone loss in women, we used MTT assay to detect young women, perimenopausal women And serum IL-6 in postmenopausal women. Serum estradiol (E2) levels were measured by radioimmunoassay. BMD of L2-4 was measured by dual-energy X-ray absorptiometry. The results showed that the serum IL-6 activity of postmenopausal women was significantly increased, but the serum E2 level was significantly lower than that of young women and perimenopausal women (P <0.01), BMD was also significantly lower than that of young women and perimenopausal women P <0.01). Correlation analysis showed that IL-6 was negatively correlated with BMD (r = -0.724, P <0.05), negatively correlated with E2 (r = -0.759, P <0.01) (R = 0.660, P <0.01). Suggesting that the lack of E2 and the consequent increase in IL-6 levels play an important role in the pathogenesis of postmenopausal osteoporosis.