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(1)通过重复使用蛋清液的方法,建立豚鼠急性支气管哮喘模型。(2)给服定喘宁后,致敏豚鼠哮喘诱发Ⅲ级反应时明显延长。(3)进一步的体内实验发现,致敏豚鼠使用定喘宁后,降低了血浆和气管组织5—羟色胺(5-HT)的含量,这个发现又是与气管组织5-羟色氨酸脱羧酶(5-HTPDC)活性的降低,与肝脏单胺氧化酶(MAO)活性升高有关。(4)实验结果表明,定喘宁的治疗是一种抑制支气管哮喘的有效方法,其机理包括从5-HT 的含量到5-HTPDC 和 MAO 活性的改变。认为这是定喘宁组方疗效的生化基础。
(1) A guinea pig model of acute bronchial asthma was established by repeated use of egg white solution. (2) After administrating Dingchuanning, sensitized guinea pigs were significantly prolonged in response to grade III responses induced by asthma. (3) Further in vivo experiments revealed that sensitized guinea pigs reduced the content of serotonin (5-HT) in plasma and tracheal tissue after using Dapthinin. This finding was in turn related to tracheal tissue 5-hydroxytryptophan decarboxylase. The decrease in the activity of (5-HTPDC) is related to the increase of liver monoamine oxidase (MAO) activity. (4) The experimental results show that the treatment of Dingchuanning is an effective method for inhibiting bronchial asthma, and the mechanism includes the change from 5-HT content to 5-HTPDC and MAO activity. It is believed that this is the biochemical basis of the efficacy of Dingchuanning prescription.