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红霉素(Erythromycin)为广谱抗生素,对G~-、G~+菌引起的感染均有较好的疗效,其常见的不良反应为胃肠道与过敏反应,对心脏的毒性罕见.本文收集10种1990～1996年国内公开发表的药学杂志,发现有7例使用红霉素患者发生了严重的心脏毒性反应,甚至为致命性的尖端扭转性空速.所收集的7例患者全是58岁以上的老年人,5女2男,6例有心脏疾患史,其中3例为口服给药,4例为静脉给药,发生时间最短为lh,最长为6d.主要表现为:多形性期前收缩及非持续性扭转性室速,Q-TC从0.4S左右延长达0.55S以上.现列表如下.
Erythromycin is a broad-spectrum antibiotic and has a good curative effect on G ~ - and G ~ + infections. The common adverse reactions are gastrointestinal and anaphylactoid reactions, which are rare in the heart. Ten published domestic journals published from 1990 to 1996 found that seven patients with erythromycin developed severe cardiotoxicity and even deadly torsadespace.The collected seven patients were all The elderly over 58 years old, 5 women and 2 men, 6 patients had a history of heart disease, of which 3 were administered orally, 4 were intravenously administered, the shortest time was lh, the longest 6d. The main performance was: Abdominal contraction and non-sustained torsades-tempo-ventricular tachycardia, Q-TC extended from about 0.4S up to 0.55S above.