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目的观察３００例不同剂量、不同年龄、不同性别、不同免疫水平的患者，注射乙肝疫苗。方法按０、１、６ｍｏ程序，三角肌内注射，全程后６ｍｏ检测表面抗体。结果表明乙肝疫苗剂量大与小产生表面抗体的阳转率无显著性差异（Ｐ＞０．０５）。注射乙肝疫苗与年龄、性别、免疫水平有显著性差异（Ｐ＜０．０１）。结论结果表明免疫效果与剂量大小无关，而与性别、年龄、机体免疫水平有关。
Objective To observe the effects of hepatitis B vaccine in 300 patients with different dosages, different ages, different genders and different immunization levels. Methods 0,1,6 mo procedure, intramyocardial injection, 6mo after the whole surface antibody detection. The results showed that there was no significant difference (P> 0.05) in the positive rate of hepatitis B vaccine when the dose was high or low. Hepatitis B vaccine injection and age, gender, immunization levels were significantly different (P <0.01). Conclusion The results show that the immune effect has nothing to do with the dose size, but with gender, age, immune level.