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目的 :观察前列腺增生症 ( BPH)并发尿潴留膀胱逼尿肌功能变化。方法 :对 10例 BPH并慢性尿潴留患者实施前列腺摘除术时取膀胱平滑肌组织进行透射电镜观察 ,同时用 1例外伤性膀胱破裂及 1例膀胱异物患者的膀胱平滑肌组织作对照。结果 :BPH并慢性尿潴留患者的膀胱平滑肌显示出下列病变 ,即平滑肌细胞肥大 ,排列紊乱 ,细胞间连接结构减少 ,其中以胞突连接为主 ,细胞内线粒体肿胀 ,胞膜有高电子密度沉积物 ,脱落细胞胞浆成分散在细胞间隙 ,平滑肌间隙以纤维组织增生为主。结论 :膀胱逼尿肌病变可以帮助我们正确理解 BPH引起的逼尿肌功能损害 ,有利于对前列腺综合征的病因分析及正确治疗。
Objective: To observe the changes of bladder detrusor function in patients with benign prostatic hyperplasia (BPH) and urinary retention. Methods: Ten cases of BPH patients with chronic urinary retention underwent prostatectomy. The bladder smooth muscle tissues were observed under transmission electron microscope. One case of bladder injury and one case of bladder foreign bodies were used as control. Results: The bladder smooth muscle of patients with BPH and chronic urinary retention showed the following pathological changes: the smooth muscle cells were hypertrophy, disorganized and the structure of intercellular connections was reduced. The majority of them were connected by cytoplasm, the mitochondria swelled and the cell membrane had high electron density deposition Material, exfoliated cell cytoplasm scattered in interstitial cells, interstitial fibrosis in the gap mainly. Conclusion: Detrusor deformity in bladder can help us correctly understand the detrusor dysfunction caused by BPH, which is beneficial to the etiological analysis and correct treatment of prostatic syndrome.