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磷酸肌醇3激酶(PI3K)信号转导在肿瘤中经常发生异常,因此很多治疗策略都聚焦在PI3K途径,侧重于下游靶分子如Akt的抑制剂等。Miao的研究小组研究了一种新的调节途径,即通过阻断关键磷脂与蛋白质的相互作用,来抑制小鼠肿瘤模
Phosphoinositide 3 kinase (PI3K) signaling is often aberrant in tumors and therefore many therapeutic strategies focus on the PI3K pathway, focusing on inhibitors of downstream target molecules such as Akt. Miao’s team studied a new regulatory pathway that inhibits mouse tumor models by blocking the interaction of key phospholipids with proteins