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目的:探讨血清维生素D水平与肺结核发病之间的关系。方法:以人群调查为基础,选择70名新发初治菌阳肺结核患者为病例组,根据性别、年龄和居住地作为配对条件1:3纳入未患结核病的健康人群对照,对资料进行均数检验、条件Logistic回归分析,维生素D水平采用Roche Cobas e601型全自动电化学发光免疫分析仪进行检测。结果:共纳入70例肺结核患者与210例健康对照人群,病例组男性的血清维生素D水平明显高于对照组男性(P<0.05),经条件Logistic回归分析也显示,血清维生素D是肺结核发病的危险因素(OR=1.04,95%CI:1.001~1.070,P<0.05)。结论:血清维生素D与肺结核的患病风险具有统计学关联,对于维生素D在影响肺结核发病中的价值,仍需在国内人群中开展更多高质量、大样本的流行病学调查验证以提供更充分的证据。
Objective: To investigate the relationship between the serum vitamin D level and the incidence of pulmonary tuberculosis. Methods: Based on the population survey, 70 newly diagnosed TB patients with positive tuberculosis were selected as the case group. According to the sex, age and residence as the matching condition 1: 3, the control group was included in the healthy population without tuberculosis. The data were averaged Test, conditional Logistic regression analysis, vitamin D levels using Roche Cobas e601 automatic electro-chemiluminescence immunoassay for testing. Results: A total of 70 patients with pulmonary tuberculosis and 210 healthy controls were enrolled in this study. The serum vitamin D levels of male patients in the case group were significantly higher than those in the control group (P <0.05). Logistic regression analysis also showed that serum vitamin D was associated with pulmonary tuberculosis Risk factors (OR = 1.04, 95% CI: 1.001 to 1.070, P <0.05). Conclusions: There is a statistical correlation between serum vitamin D and the prevalence of tuberculosis. The value of vitamin D in influencing the incidence of pulmonary tuberculosis still needs to be verified in the domestic population by more high-quality and large-scale epidemiological investigations to provide more Full evidence.