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高脂蛋白血症常伴有止血参数和血液流变学(全血粘度、红细胞压积、血浆粘度、红细胞聚集率及变形性、纤维蛋白原等)改变,血浆粘度(主要决定于纤维蛋白原)和红细胞聚集率增加。这些异常,促使动脉血管并发症危险增大。 35例原发性高脂蛋白血症(IIa型26例、IIb型9例),男18、女17例,平均年龄47.4岁。停用降脂药并予低脂饮食4周后,口服洛司他丁(lovastatin)。起始量20mg每日1次,必要时逐渐增至每日80mg;平均每日40mg。共治疗3个月。
Hyperlipoproteinemia is often accompanied by changes in hemostatic parameters and hemorheology (whole blood viscosity, hematocrit, plasma viscosity, erythrocyte aggregation and deformability, fibrinogen, etc.), plasma viscosity (mainly determined by fibrinogen ) And increased erythrocyte aggregation rate. These abnormalities contribute to the increased risk of arterial complications. 35 cases of primary hyperlipoproteinemia (IIa 26 cases, IIb 9 cases), 18 males and 17 females, with an average age of 47.4 years. Four weeks after stopping the lipid-lowering drug and giving a low-fat diet, lovastatin was taken orally. The initial amount of 20mg daily 1, if necessary, gradually increased to 80mg daily; the average daily 40mg. A total of 3 months treatment.