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一百多年前,眼科医生开始观察到家族性角膜营养不良的存在,但由于当时技术条件所限,直至本世纪初期,还不能确切地诊断这一疾病。常认为是一种单纯的变性性病变,甚至与角膜炎症相混淆(1)。现代医学及其相应的基础学科的发展,尤其是生物化学,超微结构及分子遗传学等研究技术的应用,至50年代才普遍地命名为家族遗传性角膜营养不良,且愈为广泛地为人们所重视。一、发病概况由于大多数的遗传性角膜营养不良只影响角
More than 100 years ago, ophthalmologists began to observe the existence of familial corneal dystrophy, but due to the limited technical conditions at that time, it was not possible to diagnose the disease exactly until the beginning of this century. Often considered a simple degenerative disease, even confused with corneal inflammation (1). The development of modern medicine and its corresponding basic subjects, especially the application of research techniques such as biochemistry, ultrastructure and molecular genetics, was generally referred to as familial hereditary corneal dystrophy until the 1950s and more generally People value. First, the incidence profile Because most of the hereditary corneal dystrophy only affects the angle