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目的 :了解进驻高原不同海拔高度不同居住时间健康青年血清性激素的变化情况 ,探讨激素与高原低氧的关系。方法 :对从平原进驻海拔 370 0m和 5380m高原第 7天及半年的4 0名某部官兵 ,用放射免疫分析法进行血清睾酮 (T)和雌二醇 (E2 )检验 ,并以高原居住半年返回平原 1个月的 2 0名青年及从未上过高原的 2 0名青年作对照。结果 :进驻海拔 370 0m和 5380m第 7天 ,T分别为 (6 .17± 2 .10 ) μg·L 1和 (2 .72± 1.72 ) μg·L 1,较平原对照的 (16 .58± 4 .4 4 ) μg·L 1降低非常显著 (P <0 .0 1) ;E2 分别为 (2 1.4 4± 8.36 ) μg·L 1和 (10 .2 5± 4 .2 6 ) μg·L 1,较平原对照的(43.39± 12 .10 ) μg·L 1也降低非常显著 (P <0 .0 1)。进驻海拔 370 0m和 5380m半年后T分别为(10 .6 0± 2 .89) μg·L 1和 (5.81± 2 .6 9) μg·L 1,略有回升 ,但仍显著低于两个对照组 (P <0 .0 1) ;E2分别为 (30 .2 1± 9.84 )ng·L 1和 (2 0 .38± 8.77)ng·L 1也比两个对照组低 (P <0 .0 1,P <0 .0 5)。结果表明 ,进驻高原低氧环境 ,T、E2 均较平原对照组降低 ,且随海拔高度的升高而更加降低 ,随居住的时间延长而有所回升。返回平原 1个月后 ,T仍低于平原对照组 (P <0 .0 5) ,E2 则恢复到平原对照水平。结论 :缺
Objective: To understand the changes of serum sex hormones in healthy youth at different altitudes at different altitudes in the plateau, and explore the relationship between hormones and hypoxia in the plateau. Methods: Serum testosterone (T) and estradiol (E2) were detected by radioimmunoassay (ELISA) on the 7th and 6th day after the plains were stationed in 370 0m and 5380m above sea level. 20 youths who returned to the plain one month and 20 youths who had never been on the plateau. Results: At the 7th day of altitude 370 m and 5380 m, T were (6 .17 ± 2. 10) μg · L 1 and (2.72 ± 1.72) μg · L 1 respectively, compared with that of the plain control (16.58 ± (P <0.01); E2 were (2 1.4 4 ± 8.36) μg · L 1 and (10.25 ± 4.226) μg · L -1, respectively 1, (43.39 ± 12.10) μg · L -1 was also significantly lower than that of the plain control (P <0.01). After being placed in the altitude of 370 0m and 5380m for six months, the T values were (10.60 ± 2.89) μg · L -1 and (5.81 ± 2.67) μg · L -1, respectively, but slightly lower than those of two (30.21 ± 9.84) ng · L 1 and (20.38 ± 8.77) ng · L -1, respectively, in the control group (P <0.01) .0 1, P <0. 0 5). The results showed that T, E2 in the plateau hypoxic environment decreased compared with the control group, and decreased with the increase of the altitude, and recovered with the prolongation of residence time. After 1 month of return to the plain, T was still lower than that of the plain control group (P <0.05), and E2 returned to the level of plain control. Conclusion: Lack