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目的研究赛罗群钩体病流行规律,方法用显微镜凝集试验法检测患者、水鸭和蛙血清抗体；同时分离培养病原体。用夹夜法捕鼠,采集鼠肾、猪肾、牛中段尿、蛙肾、水鸭肾和蚂蟥血分离培养病原体。结果浙江省20世纪60至80年代钩体病不断出现大规模暴发流行,90年代后疫情平稳下降。到2004年为止,全省共发生钩体病138526例,死亡933例,年平均发病率为5．86/10万,病死率为0．67％。1997至2004年全省共发生钩体病956例,平均发病率为0．27/10万,死亡14例,平均病死率为1．46％。衢州、丽水和台州市的发病数占全省发病总数的93．20％。病例主要分布在7～10月份,占94．87％。患者血清抗体阳性率为61．72％,菌群主要为黄疸出血群、七日热群和赛罗群。患者血培养阳性率为1．0％。鼠密度为4．54％,以黑线姬鼠为优势种,占52．04％。鼠带菌率为3．82％,黑线姬鼠带菌率为6．05％。蛙肾阳性率为0．41％。水鸭血清抗体阳性率为34％,菌株主要为秋季群和赛罗群；蛙血抗体阳性率为8．7％,菌株为秋季群。结论浙江省存在赛罗群钩体感染,钩体病进入低发期,需要科学监测。
Objective To study the epidemiology of Leptospira sarcoleus in Sylvilagus monocytogenes.Methods Serum antibodies against patients, ducks and frogs were detected by microscope agglutination test, and the pathogens were isolated and cultured at the same time. Catching the night with the method of catching rats, the collection of rat kidney, pig kidney, midgut urine, frog kidney, water duck kidney and leech blood separation and culture of pathogens. Results Large-scale outbreaks of leptospirosis continued to occur in Zhejiang Province from 1960s to 1980s, and the epidemic declined steadily after the 1990s. As of 2004, a total of 138,526 cases of leptospirosis occurred in the province with 933 deaths, with an average annual incidence of 5.86 / lakh and a case fatality rate of 0.67%. From 1997 to 2004, a total of 956 cases of leptospirosis were reported in the province with an average incidence of 0.27 / 100 000 and 14 deaths with an average mortality of 1.46%. The incidence of Quzhou, Lishui and Taizhou accounted for 93.20% of the total incidence in the province. The cases mainly distributed in 7 ~ October, accounting for 94.87%. Serum antibody positive rate of patients was 61.72%, mainly flora jaundice hemorrhage group, heat group on the 7th and match Luo group. The positive rate of blood culture in patients was 1.0%. Rat density was 4.54%, with Apodemus agrarius as the dominant species, accounting for 52.04%. The infection rate of rats was 3.82%, while the infection rate of Apodemus agrarius was 6.05%. Frog kidney positive rate was 0.41%. The positive rate of duck serum antibody was 34%. The main strains were autumn group and race group. The positive rate of frog blood antibody was 8.7%. The strain was autumn group. Conclusions Zhejiang Province has Sylvilaria leptospira infection, leptospirosis into the low incidence period, requiring scientific monitoring.